In short
Overview
Switching from Ozempic to Mounjaro is common when more weight loss is the goal. The doses do not convert one to one.
Direct Answer
Switching from Ozempic to Mounjaro follows a new prescription plan, because the doses of semaglutide and tirzepatide do not convert one to one. Mounjaro starts at 2.5 mg once a week for 4 weeks and rises in 2.5 mg steps every 4 weeks or more, according to the product information (Mounjaro SmPC).
Injections are never overlapped, and the review includes the reason Ozempic was prescribed, for example type 2 diabetes.
Who This Applies To
- People on Ozempic who want more weight loss.
- People with side effects on semaglutide.
- People on Ozempic for type 2 diabetes.
- People who stopped Ozempic and want to restart with another medicine.
Option Comparison / Decision Criteria
When does a switch to Mounjaro make sense?
A switch to Mounjaro makes sense when more weight loss is the goal or sleep apnoea is present. Tirzepatide produced more weight loss than semaglutide 2.4 mg in a head-to-head trial.
| Situation | Usual decision |
|---|---|
| Goal of 15 percent or more not reached | Switch considered |
| Obstructive sleep apnoea | Tirzepatide preferred |
| Heart disease without diabetes | Semaglutide kept |
| Good response and tolerance | No switch |
Why an In-Person Physician Review Matters
What does the switch review cover?
The switch review covers the last Ozempic dose and date, the response so far, side effects, diabetes medicines and contraception. Women on the pill switch to a non-oral method or add a barrier method for 4 weeks after starting tirzepatide and after each dose increase.
Frequently Asked Questions
No, the doses do not convert one to one; Mounjaro follows its own schedule.
No, the two injections are never overlapped.
Mounjaro starts at 2.5 mg weekly per the product information, and the prescriber adjusts the plan to your situation.
Yes, women on the pill switch to a non-oral method or add a barrier for 4 weeks after starting and after each dose increase.
Evidence
Where this information comes from
Every figure on this page is taken from the sources below. All of them are free to read, so you can check them yourself.
This page is general medical information and does not replace a personal consultation. Trial results are averages across large groups, not a prediction for any one person.